| 아토피 피부염 모델인 NC,Nga 마우스에 대한 편백잎 추출물의 면역조절효과에 관한 연구 |
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조소은 |
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| Research Paper : A Study on the Immunomodulatory Effects of Chamaecyparis Obtusa Leaves on NC,Nga Mice as Models for Atopic Dermatitis |
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So Eun Cho |
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| Abstract |
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In this study, a test for the immunity control effect by Chamaecyparis Obtusa Leaves(COL) extracts on NC/Nga mice as the models for atopic dermatitis was conducted with the following results. The test on the internal toxicity tests for the liver and the kidney showed that, as for the test group with COL, all of the measurement for ALT(Alanine transaminase), AST(Aspartate transaminase), BUN(Blood urea nitrogen), Creatinine were within the normal range. Also, the immunity rate of CD4+, B220+/CD23+, CD11b+/Gr-1+within PBMC showed a significant decrease compared to that of the control group. The cytokine within the blood serum, that is, IL-5, L-13, and IL-17 showed a decreased compared to the control group. Especially, the generation of Histamine decreased with statistical significance. Also, cytokine IL-4 within the spleen cells that were activated by CD3/CD28 appeared to decrease, especially with a significant decrease in IFN- |
| Key Words:
Chamaecyparis obtusa, Immunity, NC, Nga, Cytokine, Atopic dermatitis |
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