CBA/N mouse에서 한방혼합추출물이 아토피 피부염에 미치는 면역조절효과 |
박선남, 정상희, 김영원, 최옥병 |
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Immunomodulation Effect of Combined Herbal Extracts on Atopic Dermatitis in CBA/N Mouse |
Seon Nam Park, Sang Hee Jeong, Young Won Kim, Ok Byung Choi |
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Abstract |
The purpose of this study was to investigate the immune modulation effects of Herbal complex extracts through the mouse local lymph node assay(LLNA). CBA/N mice were divided into five groups including NC(acetone: olive oil, 4:1 v/v), PC(DNCB 1%), LO(Herbal Complex cream), LOPC(Mixture LO with PC) and LOAPC(applied PC after LO for 3days). There were no statistical changes in weight, food intake or water intake. Ear thickness was significantly decreased, and the total serum IgE level LOPC and LOAPC were also significantly decreased. IL-4(Interleukin- 4) and IL-5(Interleukin-5), cytokine of Th2, were increased in atopic dermatitis but significantly decreased in LOPC and LOAPC. In consequence of the above result, it is concluded that the extracts enhance the barrier of skin to protect the skin from allergic substance and suppress various inflammation activities by controlling immune factors, therefore the extracts may be useful for process prevention and improvement in atopic dermatitis. |
Key Words:
Herbal complex, local lymph node assay, IgE, IL-4, IL-5 |
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