Journal of the Korean Society of Cosmetology 2016;22(6):1160-1167.
Published online December 31, 2016.
황금 생물 전환 물질이 피부의 면역 기능과 Claudin-1에 미치는 영향
김현아, 윤미영
Effect on Skin of Immune Functioning and Claudin - 1 by using Scutellaria baicalensis Bio-conversion Substance
Hyo-na Kim, Mi-young Yun
The Scutellariae baicalensis Georgi of this study are to identify the effects of S. baicalin bio-conversion substance on atopy. The cultural technique of mycelium of red deokdari mushroom was applied into SB which is effective for atopic dermatitis. G/Baicalein was produced, which was composed of Baicalein-Aglycon and glucan formed from mycelium. The effect on immune functioning recovery and recovery mechanism of Claudin 1- mainly protein of TJ in Keratinocyte, which is composed of skin surface-was confirmed with in vitro and in vivo. This result proved effective in treating atopic dermatitis. When number of immunocyte in back dermal tissue in the test of in vivo was observed, it was meaningly reduced in group with G/Baicalein more than that of comparison group and SB. Specially, in the test to learn the effect of changes in number of immunocyte, the number of CD4+, CD8+, CD11b+/Gr-1+ cells was decreased significantly. When Claudin-1 was observed after cutting skin tissue, Claudin-1 with red fluorescent color was increased in SB and G/ Baicalein group compared with control group. Especially, Claudin-1 was remarkably increased in G/Baicalein compared with control group. According to the above result, G/Baicalein increased expression ratio of Claudin 1- mainly protein of TJ, and immune functioning recovery was confirmed. In conclusion, if G/Baicalein will be developed as substance of cosmetics for atopic dermatitis and applied for skin treatment, it will be available effectively at the treatment for atopic dermatitis.
Key Words: Bio-conversion, Claudin-1, Immunocyte, Leatiporus sulphureus var. miniatus, Scutellaria baicalensis Georgi
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