Journal of the Korean Society of Cosmetology 2009;15(3):727-734.
Published online September 30, 2009.
몰약(Commiphora molmol)의 항염증 및 화장품 약리활성에 관한 연구
장영아, 천순주, 장민정, 전동하, 조우아, 권오준, 김태훈, 김영훈, 이진태
Research Paper : Anti-inflammatory and Cosmeceutical Activies of Commiphora molmol
Young Ah Jang, Soon Ju Cheon, Min Jung Jang, Dong Ha Jun, Woo A Cho, O Jun Kwon, Tae Hun Kim, Young Hun Kim, Jin Tae Lee
Abstract
Commiphora molmol (well known myrrha) is a reddish-brown resinous material, the dried sap of the tree Commiphora molmol, native to Yemen, Somalia and the eastern parts of Ethiopia. High quality myrrha can be identified through the darkness and clarity of the resin. Limited scientific studies suggest that myrrha has antibacterial and anti-inflammatory activities. This study determined cytotoxicity of myrrha oil to Raw 264.7 cells and its effect, measured by ELISA. This study was carried out to investigate the cosmeceutical activities of Commiphora molmol methanol extracts, by measuring electron-donating ability (using DPPH), nitrite-scavenging ability, and astringent activity. Based on the MTT assay, 12 and 24h myrrha exposures to 10ppm myrrha had little effect on Raw 264.7 cell (12h only) viability. At 24 h, 10~1000ppm myrrha decreased Raw 264.7 viability 30~38%. In nitrite-scavenging ability test, myrrha inhibited nitric oxide (NO) production and blocked LPS-induced iNOS expression. The DPPH radical scavenging activity was the 88% in 500 ppm of myrrha showed electron donating ability. Astringent effect of myrrha 98% at 500ppm concentration. These results indicate of myrrha extracts may be useful as a adjuvant for cosmeceutical industry.
Key Words: Anti-inflammatory, Astringent, Commiphora molmol, Raw 264.7 cell


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