Journal of the Korean Society of Cosmetology 2009;15(4):1389-1398.
Published online December 31, 2009.
삼백초 열수추출물의 피부주름 억제효과
강성례, 민경진, 김영철
Research Paper : The Inhibitory Effects of Saururus chinensis Water Extract on Skin Wrinkle in Hairless Mice
Sung Rye Gang, Kyung Jin Min, Young Chul Kim
Abstract
To investigate the inhibitory effects of Saururus chinensis water extract (SCWE) on the skin wrinkle formation, both the irradiation of UVB and the application of squalene monohydroperoxide (Sq-OOH) were applied to the backs of experimental animals for 4 weeks and at the same time, experimental materials were applied topically. Six to seven weeks female SKH-1 hairless mice were divided into five groups including normal (N; saline), control (C; UVB+Sq-OOH+saline), vehicle control (VC; UVB+Sq-OOH+vehicle), positive control (PC; UVB+Sq-OOH+0.01% retinoic acid) and experimental (E; UVB+Sq-OOH+SCWE) groups, five animals each group. Wrinkles for the C group were formed as a pattern of deep furrows and thick crests. Whereas wrinkles for the PC and E groups were formed as a pattern of shallow furrows and thin crests. Collagen fibers in the dermis of C group were broken severely and the density was sparse. Whereas collagen fibers in the dermis of PC and E groups were almost intact with a regular arrangement. Elastosis was found in the dermis of C group with the infiltration of degenerated and clotted elastin. The activity of xanthine oxidase was significantly higher in C group compared to N group, but there was no significant difference between E group and N group. MMP-3 mRNA expression in C group was significantly higher than N group, and that of PC and E groups showed significantly lower than C group. Taken the results together, SCWE could have a considerable inhibitory efficacy on skin wrinkle formation in hairless mice, probably due to reducing oxidative stress caused by UVB irradiation and Sq-OOH application.
Key Words: Saururus chinensis, Wrinkles, Collagen Fiber, Antioxidant Enzymes, Mmp-3


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