Research Paper : The Alleviative Effects of Saururus chinensis Water Extract on Inflammation and Skin-Barrier Damage

Gang, Sung Rye; Min, Kyung Jin; Kim, Young Chul

Journal of the Korean Society of Cosmetology 2009;15(4):1399-1408.
Published online December 31, 2009.

삼백초 열수추출물의 염증 및 피부장벽 손상 완화효과

강성례, 민경진, 김영철

Research Paper : The Alleviative Effects of Saururus chinensis Water Extract on Inflammation and Skin-Barrier Damage

Sung Rye Gang, Kyung Jin Min, Young Chul Kim

Abstract

To investigate the inhibitory effects of Saururus chinensis water extract (SCWE) on the inflammation and skin barrier damage, both the irradiation of UVB and the application of squalene monohydroperoxide (Sq-OOH) were applied to the backs of experimental animals for 4 weeks. And at the same time experimental materials were applied topically. Six to seven weeks female SKH-1 hairless mice were divided into five groups including normal (N; saline), control (C; UVB+Sq-OOH+saline), vehicle control (VC; UVB+Sq-OOH+vehicle), positive control (PC; UVB+Sq-OOH+0.01% retinoic acid) and experimental (E; UVB+Sq-OOH+SCWE) groups, five animals each group. The skin erythema index for PC and E groups were lower than that of C group. Lipid and water capacities for PC and E groups were higher than those of C group. Epidermis and dermis of C group were remarkably thickened and many inflammatory cells including lymphocytes, neutrophils and macrophages were found. Whereas a few inflammatory cells were found in PC and E groups. In comparison with C group, PC and E groups showed a relatively well preserved lipid lamellae in epidermis and a relatively much less infiltration of mast cells in dermis or hypodermis. As for the both absolute and relative weight of the spleen, PC group were significantly higher than the other groups. Therefore, SCWE could have a considerable inhibitory efficacy on the inflammation and skin barrier damage induced by UVB irradiation and Sq-OOH application.

Key Words: Saururus chinensis, Hairless Mice, Skin Barrier, Inflammation, Lipid Lamella