| 인간 섬유아세포주에서 resveratrol에 의한 GADD45 alpha 유전자 발현 증가와 이를 통한 DNA 수복 |
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최수기, 이윤경, 차화준, 안성관 |
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| Research Paper : Resveratrol Activates the DNA Repair Activity by Inducing GADD45 mRNA Expression in Human Dermal Fibroblasts |
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Su Ki Choi, Yun Kyung Lee, Hwa Jun Cha, Sung Kwan An |
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| Abstract |
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In skin, dermal fibroblasts are a primary center of organization of dermis. Decrease of dermal fibroblasts through DNA damage by UV, oxidative stress and chemicals induces disorder of skin structure and homeostasis. Therefore, DNA damage protection and evasion are important in cosmetics. Resveratrol (trans-3, 4`, 5-trihydroxystilbene) is a polyphenol occurred naturally in grape and various medicinal plants. Although it has been shown that resveratrol decreases reactive oxygen species (ROS) by direct and indirect mechanism and increases the DNA repair activity, its detailed molecular mechanism has not been understood, thoroughly. Here we show that resveratrol plays a critical role in activation of the DNA repair activity by inducing GADD45 |
| Key Words:
Human dermal fibroblast, Resveratrol, DNA repair, Microarray, GADD45 alpha |
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