The Effects of Black Currant Seed Oil on Cytokine Excretion of Spleen Cells and Histopathological Changes in Atopic-like Dermatitis Model

Lee, Ye Seo; Park, Kyo Hyun; Kim, Bae Hwan

Journal of the Korean Society of Cosmetology 2016;22(3):586-592.
Published online June 30, 2016.

아토피성 피부염 동물모델에서 Black currant seed oil의 비장세포 cytokine 및 조직병리학적 변화에 미치는 영향

이예서, 박교현, 김배환

The Effects of Black Currant Seed Oil on Cytokine Excretion of Spleen Cells and Histopathological Changes in Atopic-like Dermatitis Model

Ye Seo Lee, Kyo Hyun Park, Bae Hwan Kim

Abstract

This study investigated the cytokine excretion of spleen cells and histopathological changes in atopic-like dermatitis model, and evaluated the anti-atopic effects of black currant seed oil. BALB/c mice (five-week old) were divided into four groups: N (normal group, nontreated), C (control group, induced atopic dermatitis), PC (positive control group, Tacrolimus ointment treatment for induced atopic dermatitis), and E (experiment group, Black currant seed oil treatment for induced atopic dermatitis, E). During the experiment, no significant changes were observed in feed intake, water, intake, body weight. The INF-

Key Words: Black currant seed oil, Atopic dermatitis, INF-γ, IL-4, Histopathological change