| RMC의 아토피성 피부염 발현제어효과에 관한 연구 |
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윤미영, 노영희, 정광조 |
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| Research Paper : Suppression of DNCB-induced Dermatitis in NC / Nga Mouse Model by RMC |
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Mi Young Yun, Young Hee Noh, Kwang Jo Cheong |
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| Abstract |
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Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by inflammatory cell infiltration in the skin. This study was performed to assess the therapeutic effects of RMC on the DNCB-induced dermatitis in NC / Nga mice. 1. RMC administration significantly reduced clinical dermatitis severity including pruritus, edema, eczematous and erythema. 2. Histological findings indicated that the thickening of epidermis / dermis and dermal infiltration of inflammatory cells including mast cells were dramatically reduced. 3. The level of IL-4 in CD3 / CD28 activated splenocyte was downregulated, whereas that of IFN- |
| Key Words:
Atopic Dermatitis, AD, RMC, Histological |
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