| 인체지방유래 줄기세포배양액 고분자 유화좀의 화장품 소재로서의 임상적 효용성에 관한 연구 |
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김은지1, 강상모2 |
1건국대학교 대학원 생물공학과
2건국대학교 생물공학과 |
| A Study on the Clinical Effectiveness of Human Adipose-Derived Stem Cell Conditioned Media Polymersome as a Cosmetic Material |
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Eun-ji Kim1, Sang-mo Kang2 |
1Dept. of Biological Engineering, Graduate School, Konkuk University
2Dept. of Biological Engineering, Konkuk University |
Correspondence:
Sang-mo Kang, Tel: 82-2-450-3524,
Email: kangsm@konkuk.ac.kr
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Received: 25 August 2020 • Revised: 14 October 2020 • Accepted: 14 January 2021 |
| Abstract |
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The purpose of this study was to investigate the clinical effectiveness of human adipose-derived stem cell- conditioned media (ADSC conditioned media (ADSC-CM) as a cosmetic material. To evaluate the effects of cream containing ADSC-CM 5% polymersome on human skin, subjects applied 0.8g of the research samples over the whole face for 28 days. In the experimental group (E), the moisture content increased by 12.4 percent(p<.001), and the TEWL was 5.5% increased while it was increased by 22.6% in the control group (C). Melanin index decreased by 1.6%(p<.05) and erythema index decreased by 3.2% in E(p<.01). Compared to the pre-test, the post facial skin tone was increased by 0.2% in E. E showed improvements in overall size of eye wrinkle, depth, and width by 19.1%, 12.5% and 4.3%, respectively(each p<.001). Skin roughness decreased by 9.9% in E(p<.001). Gloss value increased 7.2% in E(p<.001). In conclusion, the effectiveness of ADSC-CM polymersome was verified on all items including skin moisture content, TEWL, melanin, erythema, facial skin tone, eye wrinkle, skin roughness and gloss value. These results demonstrate that cream contained ADSC-CM polymersome has the clinical effectiveness as cosmeceuticals. |
| Key Words:
Adipose-derived Stem Cells Conditioned Medium, Cosmetics, Efficacy evaluation, Polymersome |
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