| Centella asiatica의 추출조건에 따른 항산화 및 콜라겐 합성 효능 |
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김영주 |
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| Research Paper : Effects of Centella asaitica Extracts on Anti-oxidant and Collagen Synthesis According to Extraction Conditions |
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Young Joo Kim |
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| Abstract |
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This study examined the effects of Centella asiatica (C. asiatica) extracts on anti-oxidant and collagen synthesis in both cell-free and normal human dermal fibroblast (NHDF) cell culture systems and compared differences in the effects of extracts obtained under varying extraction conditions. Extracts were prepared from either fresh or dried C. asiatica and using either H2O, absolute ethanol, or 60% ethanol as a solvent. The contents of C. asiatica extracts were analyzed by high-performance liquid chromatography, and extracts prepared from dried C. asiatica in 60% ethanol showed the highest content levels of madecassoside, asiaticoside, madecassic acid and asiatic acid. All extracts except those prepared in H2O demonstrated effects on increasing NHDF cell viability. Extracts prepared from dried C. asiatica in 60% ethanol showed the most prominent effects on NHDF cell viability and radical scavenging activity. Among the extraction conditions tested, extracts prepared fresh C. asiatica in H2O had the greatest effect on type I collagen synthesis. These results suggest that the efficacy of C. asiatica extracts can be improved by altering extraction conditions. |
| Key Words:
Centella asiatica, Extracting condition, Anti-oxidant, Collagen |
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